UCSD Cryo-EM Facility Update – March 2019

Greetings! As chair of the UCSD Cryo-EM Facility Users Committee, I will be sending regular updates to the campus community on the status of the facility as we build important new capabilities, including installation and commissioning of our newest instrument, a Titan Krios microscope. My plan is to send one short update every month. Please see the newly-updated Cryo-EM Facility web site for instructions on subscribing or un-subscribing from this list:


Our first important item is the recent release of an open call for proposals to use the new Titan Krios microscope, which is now fully operational and collecting data for campus users. Please see the facility guidelines and a link to the online proposal at the facility web site, linked below. Questions? Please contact me directly.


Second, the Titan experienced some down-time these past two weeks, but it’s worth it. FEI engineers have installed a new hardware module (“fringe-free illumination”) that will eventually enable a significant increase in data collection speed for single-particle cryo-EM, compared to existing capabilities. At the end of the day, this will mean more particles (or less time and cost) for your structure – and ours is one of the first microscopes to receive this upgrade!

Finally, as you may be aware the Cryo-EM facility has lacked a full-time manager for close to two years. We are currently interviewing candidates for this position, and hope to have an update soon.

Until next time…

Kevin Corbett